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Metoprolol tartrate

产品编号 T0487Cas号 56392-17-7
别名 酒石酸美托洛尔, CGP 2175E

Metoprolol tartrate 是一种心脏选择性β1肾上腺素阻断剂。

Metoprolol tartrate

Metoprolol tartrate

纯度: 99.93%
产品编号 T0487 别名 酒石酸美托洛尔, CGP 2175ECas号 56392-17-7

Metoprolol tartrate 是一种心脏选择性β1肾上腺素阻断剂。

规格价格库存数量
25 mg¥ 690现货
50 mg¥ 1,100现货
1 mL x 10 mM (in DMSO)¥ 592现货
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纯度:99.93%
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产品介绍

生物活性
产品描述
Metoprolol Tartrate is a blocker of the cardioselective β-adrenergic receptor.
体外活性
Metoprolol, attenuates cardiomyocyte apoptosis in left ventricular (LV) myocardium of dogs with heart failure (HF). Metoprolol induces the expression of Bcl-2 independent of heart failure (HF) and that this independently confers protection. [1]
体内活性
Metoprolol partly reverses the depressed left ventricular (LV) systolic pressure, positive and negative rates of changes in pressure development, ejection fraction, fractional shortening and cardiac output, as well as increased LV end-diastolic pressure in 20 weeks myocardial infarction (MI) rats. Metoprolol partially reverses the elevated levels of plasma norepinephrine and dopamine without affecting the elevated levels of epinephrine. [2] Metoprolol treatment attenuates the development of cardiac dysfunction in streptozotocin (STZ)-diabetic rats. Metoprolol leads to reduced rates of palmitate oxidation, stimulation of glucose oxidation, and increases tissue ATP levels. Metoprolol leads to decreased maximum activity and decreased sensitivity of carnitine palmitoyltransferase I to malonyl-CoA. Metoprolol also increases sarco(endo) plasmic reticulum Ca(2+)-ATPase expression and prevents the reexpression of atrial natriuretic peptide in diabetic hearts of in streptozotocin (STZ)-diabetic rats. [3] Metoprolol, attenuates the increase in collagen content in noninfarcted regions and prevents the increase in right ventricular weight/body weight, and its effect is similar to captopril in rat model with myocardial infarction (MI). Metoprolol treatment tends to increase right ventricular weight and heart weight. [4]
别名酒石酸美托洛尔, CGP 2175E
化学信息
分子量684.81
分子式C15H25NO3.2:1C4H6O6
CAS No.56392-17-7
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 34.2 mg/mL (100 mM)
H2O: 34.2 mg/mL (100 mM)
溶液配制表
DMSO/H2O
1mg5mg10mg50mg
1 mM1.4603 mL7.3013 mL14.6026 mL73.0130 mL
5 mM0.2921 mL1.4603 mL2.9205 mL14.6026 mL
10 mM0.1460 mL0.7301 mL1.4603 mL7.3013 mL
20 mM0.0730 mL0.3651 mL0.7301 mL3.6506 mL
50 mM0.0292 mL0.1460 mL0.2921 mL1.4603 mL
100 mM0.0146 mL0.0730 mL0.1460 mL0.7301 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

关键词

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